abstract：:Tissue folding is a fundamental process that shapes epithelia into complex 3D organs. The initial positioning of folds is the foundation for the emergence of correct tissue morphology. Mechanisms forming individual folds have been studied, but the precise positioning of folds in complex, multi-folded epithelia is less...

journal_title：Developmental cell

authors： Tozluoǧlu M,Duda M,Kirkland NJ,Barrientos R,Burden JJ,Muñoz JJ,Mao Y

更新日期：2019-11-04 00:00:00

abstract：:In this issue of Developmental Cell, Gibson and colleagues (Ramanathan et al., 2019) investigate the relationship between size and shape in epithelial cells. They find that cell size impacts cell shape, with unexpected consequences for epithelial growth and morphogenesis, particularly the clonal dynamics of epithelial...

journal_title：Developmental cell

authors： Thompson BJ

更新日期：2019-10-07 00:00:00

abstract：:In this issue of Developmental Cell, Ren et al. (2019) identify the embryonic origin of cardiac pacemaker cells in zebrafish and implicate Wnt5b in promoting their differentiation. Furthermore, canonical Wnt activation in human stem cell-derived cardiac progenitors produces functional pacemaker cells in vitro, advanci...

journal_title：Developmental cell

authors： Burns CG,Burns CE

更新日期：2019-09-23 00:00:00

abstract：:While autophagy is thought to be an essential process in some cancer cells, it is unknown if or how such cancer cells can circumvent autophagy inhibition. To address this, we developed a CRISPR/Cas9 assay with dynamic live-cell imaging to measure acute effects of knockout (KO) of autophagy genes compared to known esse...

journal_title：Developmental cell

authors： Towers CG,Fitzwalter BE,Regan D,Goodspeed A,Morgan MJ,Liu CW,Gustafson DL,Thorburn A

更新日期：2019-09-23 00:00:00

abstract：:Developmental processes that control root system architecture are critical for soil exploration by plants, allowing for uptake of water and nutrients. Conversion of the auxin precursor indole-3-butyric acid (IBA) to active auxin (indole-3-acetic acid; IAA) modulates lateral root formation. However, mechanisms governin...

journal_title：Developmental cell

authors： Michniewicz M,Ho CH,Enders TA,Floro E,Damodaran S,Gunther LK,Powers SK,Frick EM,Topp CN,Frommer WB,Strader LC

更新日期：2019-09-09 00:00:00

abstract：:Secreted molecules coordinate organ function. In a recent issue of Cell, Hudry et al. (2019) uncover a Drosophila testis-midgut interaction via cytokine and citrate signaling that regulates intestinal metabolism, spermatogenesis, and food intake. This impressive study is a striking example of the role of spatial organ...

journal_title：Developmental cell

authors： Droujinine IA,Perrimon N

更新日期：2019-08-19 00:00:00

abstract：:Macropinocytosis coordinates non-specific uptake of macromolecules and fluid. Cancers employ macropinocytosis to obtain nutrients to support their metabolic homeostasis. In this issue of Developmental Cell, Lee et al. (2019) report that glutamine deprivation boosts macropinocytosis via EGFR signaling induction, provid...

journal_title：Developmental cell

authors： Weerasekara VK,Patra KC,Bardeesy N

更新日期：2019-08-05 00:00:00

abstract：:Preventing inappropriate gene expression in time and space is as fundamental as triggering the activation of tissue- or cell-type-specific factors at the correct developmental stage and in the correct cells. Here, we study the impact of Polycomb repressive complex 2 (PRC2) function on HoxA gene regulation. We analyze ...

journal_title：Developmental cell

authors： Gentile C,Berlivet S,Mayran A,Paquette D,Guerard-Millet F,Bajon E,Dostie J,Kmita M

更新日期：2019-07-22 00:00:00

abstract：:Morphogenesis of wavy epidermal pavement cells in plants has fascinated researchers for decades. A mechanical mechanism had been proposed in which the anticlinal cell walls, forming the in-plane cell borders, feature contiguous stiff and soft zones that generate waves upon stretching. We replicated this model as desig...

journal_title：Developmental cell

authors： Bidhendi AJ,Geitmann A

更新日期：2019-07-01 00:00:00

abstract：:Two major functions of the epigenome are to regulate gene expression and to suppress transposons. It is unclear how these functions are balanced during physiological challenges requiring tissue regeneration, where exquisite coordination of gene expression is essential. Transcriptomic analysis of seven time points foll...

journal_title：Developmental cell

authors： Wang S,Zhang C,Hasson D,Desai A,SenBanerjee S,Magnani E,Ukomadu C,Lujambio A,Bernstein E,Sadler KC

更新日期：2019-07-01 00:00:00

abstract：:Embryonic organizers establish gradients of diffusible signaling molecules to pattern the surrounding cells. Here, we elucidate an additional mechanism of embryonic organizers that is a secondary consequence of morphogen signaling. Using pharmacological and localized transgenic perturbations, 4D imaging of the zebrafi...

journal_title：Developmental cell

authors： Das D,Jülich D,Schwendinger-Schreck J,Guillon E,Lawton AK,Dray N,Emonet T,O'Hern CS,Shattuck MD,Holley SA

更新日期：2019-06-17 00:00:00

abstract：:RhoA stimulates cell contractility by recruiting downstream effectors to the cortical plasma membrane. We now show that direct binding by anillin is required for effective signaling: this antagonizes the otherwise labile membrane association of GTP-RhoA to promote effector recruitment. However, since its binding to Rh...

journal_title：Developmental cell

authors： Budnar S,Husain KB,Gomez GA,Naghibosadat M,Varma A,Verma S,Hamilton NA,Morris RG,Yap AS

更新日期：2019-06-17 00:00:00

abstract：:In this issue of Developmental Cell, Yao et al. (2019) disrupt mitochondrial respiration in limb skeletal progenitors by conditionally deleting Tfam in the mouse embryo. They discover that not only is mitochondrial respiration dispensable for embryonic cartilage development, but also its elimination obviates the need ...

journal_title：Developmental cell

authors： Long F

更新日期：2019-06-03 00:00:00

abstract：:High-molecular-weight hyaluronan, a major component of the extracellular matrix, is anti-oncogenic, whereas low-molecular-weight hyaluronan is pro-oncogenic, though the mechanisms underlying the size-dependent opposite bioactivities of hyaluronan remain uncertain. We show here that treatment with high-molecular-weight...

journal_title：Developmental cell

authors： Ooki T,Murata-Kamiya N,Takahashi-Kanemitsu A,Wu W,Hatakeyama M

更新日期：2019-05-20 00:00:00

abstract：:It has recently been reported that a common side effect of translation-blocking morpholino antisense oligonucleotides is the induction of a set of innate immune response genes in Xenopus embryos and that splicing-blocking morpholinos lead to unexpected off-target mis-splicing events. Here, we present an analysis of al...

journal_title：Developmental cell

authors： Paraiso KD,Blitz IL,Zhou JJ,Cho KWY

更新日期：2019-05-20 00:00:00

abstract：:The effect of intracellular vesicle trafficking on stem-cell behavior is largely unexplored. We screened the Drosophila sorting nexins (SNXs) and discovered that one, SH3PX1, profoundly affects gut homeostasis and lifespan. SH3PX1 restrains intestinal stem cell (ISC) division through an endocytosis-autophagy network t...

journal_title：Developmental cell

authors： Zhang P,Holowatyj AN,Roy T,Pronovost SM,Marchetti M,Liu H,Ulrich CM,Edgar BA

更新日期：2019-05-20 00:00:00

abstract：:The NAD+-dependent deacetylase Sirtuin 1 (SIRT1) is down-regulated in triple-negative breast cancer. To determine the mechanistic basis by which reduced SIRT1 expression influences processes related to certain aggressive cancers, we examined the consequences of depleting breast cancer cells of SIRT1. We discovered tha...

journal_title：Developmental cell

authors： Latifkar A,Ling L,Hingorani A,Johansen E,Clement A,Zhang X,Hartman J,Fischbach C,Lin H,Cerione RA,Antonyak MA

更新日期：2019-05-06 00:00:00

abstract：:Epithelial cells acquire mesenchymal characteristics during development, wound healing and inflammation, and in cancer and fibrosis. With increasing appreciation of different roles of epithelial-mesenchymal transition (EMT), we address the question of how to define and recognize EMT processes and discuss their propert...

journal_title：Developmental cell

authors： Derynck R,Weinberg RA

更新日期：2019-05-06 00:00:00

abstract：:Reactive oxygen species (ROS), despite having damaging roles, serve as signaling molecules regulating diverse biological and physiological processes. Employing in vivo genetic studies in Drosophila, we show that besides causing G1-S arrest by activation of Dacapo, ROS can simultaneously inhibit cell growth by regulati...

journal_title：Developmental cell

authors： Toshniwal AG,Gupta S,Mandal L,Mandal S

更新日期：2019-05-06 00:00:00

abstract：:The correct assignment of cell fate within fields of multipotent progenitors is essential for accurate tissue diversification. The first lymphatic vessels arise from pre-existing veins after venous endothelial cells become specified as lymphatic progenitors. Prox1 specifies lymphatic fate and labels these progenitors;...

journal_title：Developmental cell

authors： Baek S,Oh TG,Secker G,Sutton DL,Okuda KS,Paterson S,Bower NI,Toubia J,Koltowska K,Capon SJ,Baillie GJ,Simons C,Muscat GEO,Lagendijk AK,Smith KA,Harvey NL,Hogan BM

更新日期：2019-04-22 00:00:00

abstract：:Optimal cell performance depends on cell size and the appropriate relative size, i.e., scaling, of the nucleus. How nuclear scaling is regulated and contributes to cell function is poorly understood, especially in skeletal muscle fibers, which are among the largest cells, containing hundreds of nuclei. Here, we presen...

journal_title：Developmental cell

authors： Windner SE,Manhart A,Brown A,Mogilner A,Baylies MK

更新日期：2019-04-08 00:00:00

abstract：:The mechanism of how organ shape emerges and specifies cell fate is not understood. Pancreatic duct and endocrine lineages arise in a spatially distinct domain from the acinar lineage. Whether these lineages are pre-determined or settle once these niches have been established remains unknown. Here, we reconcile these ...

journal_title：Developmental cell

authors： Nyeng P,Heilmann S,Löf-Öhlin ZM,Pettersson NF,Hermann FM,Reynolds AB,Semb H

更新日期：2019-04-08 00:00:00

abstract：:What are the thermodynamic costs of development? In this issue of Developmental Cell, Rodenfels et al. (2019) demonstrate that the high energetic cost of coordinated cell division that is regulated by phospho-signaling gives rise to a measurable periodicity in the heat dissipated during zebrafish embryogenesis. ...

journal_title：Developmental cell

authors： Foster PJ,Razo-Mejia M,Phillips R

更新日期：2019-03-11 00:00:00

abstract：:Tumor extracellular vesicles (EVs) mediate the communication between tumor and stromal cells mostly to the benefit of tumor progression. Notably, tumor EVs travel in the bloodstream, reach distant organs, and locally modify the microenvironment. However, visualizing these events in vivo still faces major hurdles. Here...

journal_title：Developmental cell

authors： Hyenne V,Ghoroghi S,Collot M,Bons J,Follain G,Harlepp S,Mary B,Bauer J,Mercier L,Busnelli I,Lefebvre O,Fekonja N,Garcia-Leon MJ,Machado P,Delalande F,López AA,Silva SG,Verweij FJ,van Niel G,Djouad F,Peinado H,Ca

更新日期：2019-02-25 00:00:00

abstract：:Tight junctions contribute to epithelial barrier function by selectively regulating the quantity and type of molecules that cross the paracellular barrier. Experimental approaches to evaluate the effectiveness of tight junctions are typically global, tissue-scale measures. Here, we introduce Zinc-based Ultrasensitive ...

journal_title：Developmental cell

authors： Stephenson RE,Higashi T,Erofeev IS,Arnold TR,Leda M,Goryachev AB,Miller AL

更新日期：2019-02-25 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) enables cells to gain migratory and invasive features underlined by major transcriptional and epigenetic reprogramming. However, most studies have focused on the endpoints of the EMT process, and the epistatic hierarchy of the transcriptional networks underlying EMT has remained...

journal_title：Developmental cell

authors： Meyer-Schaller N,Cardner M,Diepenbruck M,Saxena M,Tiede S,Lüönd F,Ivanek R,Beerenwinkel N,Christofori G

更新日期：2019-02-25 00:00:00

abstract：:To maintain proper organ size, nature has devised trans-organ communication systems-involving both paracrine and circulating regulatory factors-to safeguard homeostasis. In this issue of Developmental Cell, Ji et al. (2019) now describe an enterohepatic feedback loop that balances tissue size and function in the mamma...

journal_title：Developmental cell

authors： Merrell AJ,Stanger BZ

更新日期：2019-02-25 00:00:00

abstract：:Neurite fasciculation through contact-dependent signaling is important for the wiring and function of the neuronal circuits. Here, we describe a type of axon-dendrite fasciculation in C. elegans, where proximal dendrites of the nociceptor PVD adhere to the axon of the ALA interneuron. This axon-dendrite fasciculation ...

journal_title：Developmental cell

authors： Chen CH,Hsu HW,Chang YH,Pan CL

更新日期：2019-01-28 00:00:00

abstract：:Pancreatic beta cells have been shown to be heterogeneous at multiple levels. However, spatially interrogating transcriptional heterogeneity in the intact tissue has been challenging. Here, we developed an optimized protocol for single-molecule transcript imaging in the intact pancreas and used it to identify a sub-po...

journal_title：Developmental cell

authors： Farack L,Golan M,Egozi A,Dezorella N,Bahar Halpern K,Ben-Moshe S,Garzilli I,Tóth B,Roitman L,Krizhanovsky V,Itzkovitz S

更新日期：2019-01-07 00:00:00

abstract：:The combination of fluid and mechanical properties exhibited by cell membranes enables a wealth of physical phenomena, many of which also have biological functions. A recent study in Cell (Shi et al., 2018) now shows that membrane tension in the cell may not be as simple as it first seemed. ...

journal_title：Developmental cell

authors： Groves JT

更新日期：2019-01-07 00:00:00

abstract：:The blood brain barrier (BBB) is critical to ensure proper nervous system function and organismal health. In this issue of Developmental Cell, Babatz and colleagues explore the mechanisms of BBB maintenance and uncover a potential evolutionary link by which BBB glia construct paracellular barriers to ensure uninterrup...

journal_title：Developmental cell

authors： Coutinho-Budd J

更新日期：2018-12-17 00:00:00

abstract：:Many human genes generate mRNAs with alternative 3' untranslated regions (3' UTRs), which can modulate protein function. In a recent Cell paper, Ma and Mayr (2018) unveil a major membraneless organelle, termed the TIS granule-endoplasmic reticulum (TIGER), which enables specific 3' UTRs to encipher protein localizatio...

journal_title：Developmental cell

authors： Portz B,Shorter J

更新日期：2018-12-03 00:00:00

abstract：:The cilia and cell cycles are inextricably linked. Centrioles in the basal body of cilia nucleate the ciliary axoneme and sequester pericentriolar matrix (PCM) at the centrosome to organize the mitotic spindle. Cilia themselves respond to growth signals, prompting cilia resorption and cell cycle re-entry. We describe ...

journal_title：Developmental cell

authors： Ford MJ,Yeyati PL,Mali GR,Keighren MA,Waddell SH,Mjoseng HK,Douglas AT,Hall EA,Sakaue-Sawano A,Miyawaki A,Meehan RR,Boulter L,Jackson IJ,Mill P,Mort RL

更新日期：2018-11-19 00:00:00

abstract：:Steroid hormones have long been thought to enter target cells via passive diffusion through the plasma membrane. Now, reporting in Developmental Cell, Okamoto et al. (2018) demonstrate that, at least for Drosophila, steroid hormones require a protein transporter for cellular entry. ...

journal_title：Developmental cell

authors： Neuman SD,Bashirullah A

更新日期：2018-11-05 00:00:00

abstract：:The biogenesis of lipid droplets (LDs) and the development of adipocytes are two key aspects of mammalian fat storage. SEIPIN, an integral membrane protein of the endoplasmic reticulum (ER), plays a critical role in both LD formation and adipogenesis. The molecular function of SEIPIN, however, has yet to be elucidated...

journal_title：Developmental cell

authors： Yan R,Qian H,Lukmantara I,Gao M,Du X,Yan N,Yang H

更新日期：2018-10-22 00:00:00

abstract：:Metastasizing breast carcinoma cells have been hypothesized to mobilize tissue-invasive activity by co-opting the proteolytic systems employed by normal mammary epithelial cells undergoing branching morphogenesis. However, the critical effectors underlying morphogenesis remain unidentified, and their relationship to b...

journal_title：Developmental cell

authors： Feinberg TY,Zheng H,Liu R,Wicha MS,Yu SM,Weiss SJ

更新日期：2018-10-22 00:00:00

abstract：:The intestine is an organ with an exceptionally high rate of cell turnover, and perturbations in this process can lead to severe diseases such as cancer or intestinal atrophy. Nutrition has a profound impact on intestinal volume and cellular architecture. However, how intestinal homeostasis is maintained in fluctuatin...

journal_title：Developmental cell

authors： Mattila J,Kokki K,Hietakangas V,Boutros M

更新日期：2018-10-08 00:00:00

abstract：:The gut absorbs dietary nutrients and provides a barrier to xenobiotics and microbiome metabolites. To cope with toxin exposures, the intestinal epithelium is one of the most rapidly proliferating tissues in the body. The stem cell niche supplies essential signaling factors including Wnt proteins secreted by subepithe...

journal_title：Developmental cell

authors： Chee YC,Pahnke J,Bunte R,Adsool VA,Madan B,Virshup DM

更新日期：2018-09-24 00:00:00

abstract：:Egg production declines with age in many species, a process linked with stem cell loss. Diet-dependent signaling has emerged as critical for stem cell maintenance during aging. Follicle stem cells (FSCs) in the Drosophila ovary are exquisitely responsive to diet-induced signals including Hedgehog (Hh) and insulin-IGF ...

journal_title：Developmental cell

authors： Singh T,Lee EH,Hartman TR,Ruiz-Whalen DM,O'Reilly AM

更新日期：2018-09-24 00:00:00

abstract：:How cold-blooded animals acclimate to temperature and what determines the limits of their viable temperature range are not understood. Here, we show that Drosophila alter their dietary preference from yeast to plants when temperatures drop below 15°C and that the different lipids present in plants improve survival at ...

journal_title：Developmental cell

authors： Brankatschk M,Gutmann T,Knittelfelder O,Palladini A,Prince E,Grzybek M,Brankatschk B,Shevchenko A,Coskun Ü,Eaton S

更新日期：2018-09-24 00:00:00